Overview
In 2021, in the height of the COVID-19 pandemic, Automata worked with the University Hospital Southampton (UHS) NHS Foundation Trust to automate Reverse Transcript Loop-mediated isothermal amplification (RT-LAMP) testing.
In 2021, in the height of the COVID-19 pandemic, Automata worked with the University Hospital Southampton (UHS) NHS Foundation Trust to automate Reverse Transcript Loop-mediated isothermal amplification (RT-LAMP) testing.
In June 2020, a pilot programme for weekly coronavirus (COVID-19) testing began, using a ‘no-swab’ saliva test. Saliva is tested for COVID-19 using RT-LAMP-based detection procedure.
The decision to utilise this process was driven by the advantages it has when compared to the more widely used Polymerase Chain Reaction (RT-PCR) method. RT-LAMP tests can be turned around more rapidly, and the process also has no swab constraints. Additionally, RT-LAMP has a higher sensitivity and specificity than antigen lateral flow devices.
The UHS subsequently set up a new programme using non-invasive saliva collection to deliver COVID-19 test results to participating schools, colleges, universities and other participating settings within 24-48 hours.
The UHS was tasked with delivering a testing programme to cover the local population of Hampshire and the Isle of Wight. In order to enable testing for a wider section of the community, significant expansion in testing capacity and a substantial increase in the number of daily processed tests was required.
The UHS required an automation solution for aliquoting saliva, and an automation partner that could work flexibly and deliver rapidly. This was critical, as it was during a time when national institutions were competing to expand testing and recruiting from an already stretched diagnostic workforce pool. Indeed, nationally, The Institute of Biomedical Science estimates that in 2021, the demand for testing in UK molecular microbiology labs has jumped from around 300,000 a year, to 300,000 every single day.
Automata was initially working with the UHS as a robotic supplier, but as the programme continued, their relationship grew into a partnership. The versatility of Automata Labs, and its technology, allowed Automata to design bespoke solutions, with systems reprogrammed live on-site to meet changing requirements.
Working alongside engineers from the programme, Automata developed a proof of concept, demonstrating and testing it before moving to full production. The design, testing, manufacture and installation of automated liquid handling systems took six months end-to-end, including production and design time. Due to the flexibility of Automata’s automation approach, the design was able to evolve with the UHS’ changing needs while still in production.
The results have been transformative. Automation has supported the UHS in processing unprecedented volumes of tests per day for the existing facility, reducing the role of human error. It has also made lab practices safer for staff compared to previous solutions and removed humans from potential exposure to biohazardous substances during the process, protecting them from infection.
The success of the partnership has led Automata and UHS to explore further opportunities for how Automata can automate other manual elements of the existing RT-LAMP testing process, and partner further with UHS to streamline other complementary diagnostic processes.